Declan schreef op 18 april 2018 12:45:
Maarten_B Maarten_B 18 apr 2018 om 09:32
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MotisIEX schreef op 18 apr 2018 om 08:46:
Ondertussen wordt het onderzoek naar toepassingsgebied Ruconest op IRI/DGF voortgezet. Redelijk positieve resultaten dusverre! Publicatie van resultaten van een fase I/II onderzoek, publicatiedatum 10 april 2018.
Ik kan alleen het abstract plaatsen (auteursrechten, blabla). In abstract geen melding van rhC1INH (alleen van C1INH), maar in volledige publicatie is wel degelijk sprake van rhC1INH.
Abstract
Delayed graft function (DGF) is defined as need for dialysis early post-transplant. DGF is related to ischemia reperfusion injury (IRI) that diminishes allograft function and may be complement dependent. Here, we investigate the ability of C1 esterase inhibitor (C1INH) to prevent IRI/DGF in kidney transplant recipients. 70 patients receiving cadaver kidney transplants at risk for DGF were randomized to receive C1INH 50 U/kg (#35) or placebo (#35) intraoperatively and at 24 hours. The primary endpoint was need for hemodialysis during the first week post-transplant. Assessments of GFR and dialysis dependency were accomplished. Complications and safety of therapy were recorded. Similar characteristics with no significant differences in cold-ischemia time or risk factors for DGF were seen. C1INH did not result in reduction of dialysis sessions at 1 week post-transplant, but significantly fewer dialysis sessions(p=0.0232) were required 2-4 weeks post-transplant. Patients at highest risk for DGF (KDPI =85) benefited most from C1INH therapy. Significantly better renal function was seen at one year in C1INH patients (p=0.006). No significant adverse events were noted with C1INH. Although the primary end point was not met, significant reductions in need for dialysis and improvements in long-term allograft function were seen with C1INH treatment.
This article is protected by copyright. All rights reserved.
Bron: onlinelibrary.wiley.com/doi/abs/10.11...
Ik weet vrijwel zeker dat dit geen studie is met Ruconest, maar met Berinert.
Quote..
Maarten dit is jouw posting kijk even naar het kopje van de schrijver daar staat toch wel degelijk Ruconest.
Sorrie voor de late reactie !
Verder geen probleem.
Ruud..