C200 schreef op 6 november 2018 11:38:
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Eerder door Galapagos. Ziekte van Crohn
CF-MEV-107: Crohn's disease
Inflammatory bowel disease (IBD) encompasses a spectrum of diseases affecting the gastrointestinal tract. The most common are Crohn's disease and ulcerative colitis. IBD is a chronic and often recurring inflammation of the intestines with unknown cause and limited treatment options. In the most severe cases of Crohn's disease, the patients suffer from perianal fistulas that significantly affect regular activity and may lead to complications such an increased risk of cancer and life-threating systemic inflammation. In Europe, the current treatment of Crohn's disease is focused on anti-TNF-alpha therapy whereas anti-integrin biologics are an alternative available in the US. Perianal fistulas often do not respond to these systemic treatments. Several clinical trials are ongoing to target perianal fistulas using allogeneic mesenchymal stem cells (MSCs) with very positive results.